SCHEMBL14489282

SCHEMBL14489282

CC(C)c1cc(Oc2c(Cl)cc(C(=O)NCC(=O)O)c3c2CCC3)ccc1O

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 15/20 0.82
THRB P10828 15/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5408047 0.90 THRA (1.00) THRATHRB
SCHEMBL4530357 0.82 THRA (0.71) THRATHRB
SCHEMBL14489390 0.82 THRA (0.61) THRATHRB
SCHEMBL14489213 0.80 THRB (0.82) THRATHRB
SCHEMBL14489298 0.79 THRB (0.58) THRATHRB
SCHEMBL14488957 0.78 THRA (0.81) THRATHRB
SCHEMBL8894466 0.75 THRA (0.71) THRATHRB
SCHEMBL5407862 0.75 THRB (0.72) THRATHRB
SCHEMBL3805348 0.75 THRA (0.57) THRATHRB
SCHEMBL14489314 0.74 THRA (0.66) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed