Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 19/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.56 |
| ▸ | GAK | O14976 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | BUB1 | O43683 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | STK17B | O94768 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14489918 | 0.95 | FBP1 (0.68) | FBP1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL14489872 | 0.95 | EGFR (0.66) | FBP1EGFRERBB2GAKALDH1A1 | |
| Hydrochloric Acid SCHEMBL5432960 | 0.94 | EGFR (0.65) | FBP1EGFRERBB2GAKALDH1A1 | |
| SCHEMBL14489921 | 0.93 | EGFR (0.67) | FBP1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL12536524 | 0.92 | FBP1 (0.67) | FBP1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL14489919 | 0.90 | FBP1 (0.65) | FBP1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL14489912 | 0.88 | EGFR (0.72) | FBP1EGFRERBB2GAKALDH1A1 | |
| SCHEMBL14489926 | 0.88 | EGFR (0.57) | FBP1EGFRERBB2ABL1PDGFRB | |
| SCHEMBL14489923 | 0.88 | EGFR (0.70) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL14490008 | 0.87 | FBP1 (0.69) | FBP1EGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068552-A1 | BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-21 | — | — | WO | disclosed |
| US-20070135463-A1 | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same | HIMMELSBACH FRANK | 2007-06-14 | — | — | US | disclosed |
| US-20070135463-A1 | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same | HIMMELSBACH FRANK | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135463-A1 | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same | BPHL, CYP11B2, CYP11B1 | FBP1 1088/4885EGFR 349/4885ERBB2 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.