Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.55 |
| ▸ | MERTK | Q12866 | 5/20 | 0.54 |
| ▸ | AXL | P30530 | 4/20 | 0.54 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10216178 | 0.91 | MET (0.63) | METMERTKAXLATRAVPR2 | |
| SCHEMBL30452977 | 0.91 | MET (0.66) | METMERTKAXLATRAVPR2 | |
| SCHEMBL488613 | 0.91 | MET (0.66) | METMERTKAXLATRAVPR2 | |
| SCHEMBL10217468 | 0.90 | MET (0.62) | METMERTKAXLATRAVPR2 | |
| SCHEMBL10217711 | 0.89 | MET (0.60) | METMERTKAXLATRAVPR2 | |
| SCHEMBL10217479 | 0.88 | MET (0.59) | METMERTKAXLATRAVPR2 | |
| SCHEMBL10217507 | 0.87 | MET (0.62) | METMERTKAXLAVPR2AVPR1A | |
| SCHEMBL10217418 | 0.87 | MET (0.62) | METMERTKAXLAVPR2AVPR1A | |
| SCHEMBL10217699 | 0.87 | MERTK (0.57) | METMERTKAXLATRAVPR2 | |
| SCHEMBL10217502 | 0.87 | MET (0.62) | METMERTKAXLAVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |