SCHEMBL14495702 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	TRPV4	Q9HBA0	2/20	0.59

▸	ACKR3	P25106	1/20	0.43

▸	CCR1	P32246	5/20	0.41

▸	SLC6A2	P23975	1/20	0.40

▸	SLC6A4	P31645	1/20	0.40

▸	DRD2	P14416	5/20	0.39

▸	DRD3	P35462	4/20	0.39

▸	TAS1R3	Q7RTX0	2/20	0.39

▸	TAS1R1	Q7RTX1	2/20	0.39

▸	DRD4	P21917	1/20	0.37

▸	HTR2A	P28223	2/20	0.36

▸	HTR7	P34969	2/20	0.36

▸	HTR6	P50406	2/20	0.36

▸	SLC2A1	P11166	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL14495701	0.89	TRPV4 (0.59)	TRPV4ACKR3CCR1SLC6A2SLC6A4
SCHEMBL5004432	0.87	TRPV4 (0.78)	TRPV4ACKR3CCR1SLC6A2SLC6A4
SCHEMBL5007798	0.82	TRPV4 (0.68)	TRPV4ACKR3CCR1SLC6A2SLC6A4
SCHEMBL4980366	0.77	TRPV4 (0.80)	TRPV4ACKR3CCR1TAS1R3TAS1R1
SCHEMBL5004275	0.75	TRPV4 (0.87)	TRPV4ACKR3CCR1TAS1R3TAS1R1
SCHEMBL5007988	0.75	TRPV4 (1.00)	TRPV4ACKR3CCR1TAS1R3TAS1R1
SCHEMBL5004499	0.75	TRPV4 (1.00)	TRPV4ACKR3CCR1TAS1R3TAS1R1
SCHEMBL29353598	0.75	TRPV4 (1.00)	TRPV4ACKR3CCR1TAS1R3TAS1R1
SCHEMBL28218477	0.75	TRPV4 (1.00)	TRPV4ACKR3CCR1TAS1R3TAS1R1
SCHEMBL4993946	0.74	TRPV4 (0.84)	TRPV4ACKR3CCR1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2007070865-A2	PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS	SMITHKLINE BEECHAM CORPORATION (US)	2007-06-21	—	—	WO	disclosed