Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441100 | 0.88 | IDO1 (0.50) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL170305 | 0.82 | SIGMAR1 (0.55) | SIGMAR1IDO1CYP3A4MAPT | |
| SCHEMBL21835602 | 0.82 | SIGMAR1 (0.55) | SIGMAR1IDO1CYP3A4MAPT | |
| SCHEMBL10797644 | 0.82 | SIGMAR1 (0.55) | SIGMAR1IDO1CYP3A4MAPT | |
| SCHEMBL7041284 | 0.82 | SIGMAR1 (0.55) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL23023068 | 0.82 | SIGMAR1 (0.55) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL1823141 | 0.82 | SIGMAR1 (0.55) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL27779884 | 0.81 | SIGMAR1 (0.47) | SIGMAR1IDO1CYP3A4MAPTCYP1A2 | |
| SCHEMBL16403517 | 0.81 | SIGMAR1 (0.44) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL1318063 | 0.81 | ALDH1A1 (0.52) | SIGMAR1IDO1THRBACP3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070506-A2 | DIAZA HETEROCYCLIC SULFONAMIDE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2007-06-21 | — | — | WO | disclosed |