Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 6/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pibrozelesin SCHEMBL29352513 | 0.99 | P4HB (0.44) | P4HBHSP90AA1PDE1APDE1BPDE1C | |
| SCHEMBL7469393 | 0.91 | P4HB (0.41) | P4HBHSP90AA1PDE1APDE1BPDE1C | |
| SCHEMBL7474659 | 0.83 | P4HB (0.37) | P4HBHSP90AA1HRH4CFDSYK | |
| SCHEMBL14012235 | 0.80 | HRH4 (0.45) | HRH4POLB | |
| SCHEMBL13410096 | 0.80 | HRH4 (0.34) | HRH4 | |
| SCHEMBL13401447 | 0.79 | SYK (0.39) | HRH4SYK | |
| SCHEMBL2109409 | 0.79 | — | — | |
| Bromide SCHEMBL2036664 | 0.79 | — | — | |
| SCHEMBL13401608 | 0.79 | TSHR (0.34) | HRH4 | |
| SCHEMBL14012308 | 0.79 | TSHR (0.34) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235578-B2 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom | AUCKLAND UNISERVICES LIMITED (NZ) | 2007-06-26 | — | — | US | disclosed |
| US-7235578-B2 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom | AUCKLAND UNISERVICES LIMITED (NZ) | 2007-06-26 | — | — | US | disclosed |