Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642392 | 1.00 | KMT2A (0.39) | KMT2AMAPTMEN1ALDH1A1TNK2 | |
| SCHEMBL14499417 | 1.00 | KMT2A (0.39) | KMT2AMAPTMEN1ALDH1A1TNK2 | |
| SCHEMBL5638611 | 0.83 | TNK2 (0.35) | KMT2AMEN1ALDH1A1TNK2KDM4E | |
| SCHEMBL3500438 | 0.82 | TNK2 (0.44) | KMT2AMEN1ALDH1A1TNK2KDM4E | |
| SCHEMBL9876349 | 0.80 | KDM4E (0.39) | KMT2AMEN1ALDH1A1TNK2KDM4E | |
| SCHEMBL412542 | 0.80 | ALDH1A1 (0.39) | KMT2AMEN1ALDH1A1TNK2KDM4E | |
| SCHEMBL863095 | 0.80 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1TNK2KDM4E | |
| SCHEMBL6163169 | 0.79 | SCN4A (0.50) | KMT2AMAPTALDH1A1KDM4ERAB9A | |
| SCHEMBL222919 | 0.78 | MEN1 (0.43) | KMT2AMEN1ALDH1A1TNK2RAB9A | |
| SCHEMBL15093765 | 0.78 | MEN1 (0.43) | KMT2AMEN1ALDH1A1TNK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |