Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | CES1 | P23141 | 3/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 3/20 | 0.53 |
| ▸ | RARB | P10826 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499473 | 1.00 | NPC1 (0.60) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL14499477 | 1.00 | NPC1 (0.60) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL14499470 | 0.99 | NPC1 (0.61) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL5640767 | 0.96 | RAB9A (0.61) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL5637997 | 0.91 | NPC1 (0.65) | NPC1RAB9ACES1HDAC6CA1 | |
| SCHEMBL14499476 | 0.87 | FAAH (0.57) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL14499480 | 0.87 | FAAH (0.57) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL14499472 | 0.87 | FAAH (0.57) | NPC1RAB9ACES1HDAC6HDAC3 | |
| SCHEMBL7333177 | 0.85 | RARB (0.57) | NPC1RAB9AHDAC6HDAC3HDAC4 | |
| SCHEMBL14499469 | 0.85 | FAAH (0.55) | NPC1RAB9ACES1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |