Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 9/20 | 0.72 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.56 |
| ▸ | ITGAV | P06756 | 3/20 | 0.56 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.56 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.56 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.56 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.56 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | MDM4 | O15151 | 1/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.50 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14532475 | 0.86 | ITGB3 (0.53) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL14501721 | 0.82 | ITGB3 (0.51) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL242674 | 0.80 | ITGB3 (0.55) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| Trifluoroacetic Acid SCHEMBL3835281 | 0.80 | ITGB3 (0.54) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL6778499 | 0.80 | ITGB3 (0.51) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL6782755 | 0.79 | ITGB3 (0.51) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL6778398 | 0.79 | ITGB3 (0.59) | GPR139ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL1285808 | 0.77 | NPC1 (0.63) | GPR139MEN1KMT2AATMNPC1 | |
| SCHEMBL29417854 | 0.77 | NPC1 (0.63) | GPR139MEN1KMT2AATMNPC1 | |
| SCHEMBL3835347 | 0.77 | GPR139 (0.52) | GPR139ITGB3ITGB1ITGAVITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220824-B1 | Integrin-mediated drug targeting | BAYER AKTIENGESELLSCHAFT (DE) | 2007-05-22 | — | — | US | disclosed |