Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.30 |
| ▸ | CHRNG | P07510 | 1/20 | 0.30 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | CHRND | Q07001 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407037 | 0.85 | CYP3A4 (0.36) | CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL12271041 | 0.80 | SLC6A3 (0.33) | CYP3A4SMN1; SMN2KMT2ASLC6A4SLC6A3 | |
| SCHEMBL14503479 | 0.80 | CYP3A4 (0.33) | CYP3A4HPGD | |
| SCHEMBL12270797 | 0.79 | NOS2 (0.47) | SMN1; SMN2LMNASCN4ACHRNB2SLC6A2 | |
| SCHEMBL5377516 | 0.77 | SMN1; SMN2 (0.40) | CYP3A4SMN1; SMN2LMNASCN4AKMT2A | |
| SCHEMBL1555060 | 0.76 | CYP3A4 (0.41) | CYP3A4SMN1; SMN2LMNASCN4AKMT2A | |
| SCHEMBL12270783 | 0.76 | CYP3A4 (0.31) | CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL2407880 | 0.75 | CYP3A4 (0.46) | CYP3A4KMT2AHPGDSLC6A2SLC6A4 | |
| SCHEMBL13476066 | 0.74 | HPGD (0.49) | CYP3A4SMN1; SMN2KMT2AHPGDKDM4E | |
| SCHEMBL2408889 | 0.73 | HPGD (0.51) | CYP3A4SMN1; SMN2KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217701-B2 | Intracellular calcium concentration increase inhibitors | KATSUHIKO MIKOSHIBA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217701-B2 | Intracellular calcium concentration increase inhibitors | KATSUHIKO MIKOSHIBA (JP) | 2007-05-15 | — | — | US | disclosed |