Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147907 | 0.90 | PTGS2 (0.56) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8290876 | 0.87 | PTGS2 (0.73) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL14504863 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL7463985 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL8925551 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL14504430 | 0.84 | PTGS2 (0.63) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL5149058 | 0.84 | PTGS2 (0.65) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL8925421 | 0.83 | PTGS2 (0.81) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL677751 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 | |
| SCHEMBL7528008 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112037-A1 | Pyrazole Derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-20070112037-A1 | Pyrazole Derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-7183306-B2 | Pyrazole derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-27 | — | — | US | disclosed |
| US-7183306-B2 | Pyrazole derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112037-A1 | Pyrazole Derivatives | CYP11B2, CYP11B1, CYP3A43 | PTGS2 1780/4885PTGS1 1105/4885ABCB11 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.