SCHEMBL14508136

SCHEMBL14508136

CC1(C)c2ccccc2-c2ccc(-c3ccc4c(c3)C(C)(C)c3cc(-c5ccccc5-c5ccccn5)ccc3-4)cc21

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 9/20 0.50
KDM4E B2RXH2 2/20 0.37
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
POLB P06746 1/20 0.37
CCR1 P32246 1/20 0.37
CCR5 P51681 1/20 0.37
CCR8 P51685 1/20 0.37
METAP1 P53582 1/20 0.37
BLM P54132 1/20 0.37
HIF1A Q16665 1/20 0.37
DOHH Q9BU89 1/20 0.37
P4HTM Q9NXG6 1/20 0.37
TGFBR1 P36897 4/20 0.36
BRD4 O60885 1/20 0.36
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
GRM5 P41594 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14508139 1.00 PDK2 (0.50) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508175 0.97 PDK2 (0.49) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508166 0.95 PDK2 (0.50) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508228 0.94 PDK2 (0.57) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508135 0.93 PDK2 (0.53) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508137 0.92 PDK2 (0.46) PDK2KDM4ENPC1LMNABLM
SCHEMBL14508152 0.92 PDK2 (0.54) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508194 0.92 PDK2 (0.54) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL14508156 0.92 PDK2 (0.54) PDK2KDM4ENPC1LMNACYP1A2
SCHEMBL13388754 0.91 PDK2 (0.59) PDK2KDM4ENPC1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070122652-A1 Compound and organic electroluminescent device using same CANON KABUSHIKI KAISHA (JP) 2007-05-31 US disclosed
US-20070122652-A1 Compound and organic electroluminescent device using same CANON KABUSHIKI KAISHA (JP) 2007-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070122652-A1 Compound and organic electroluminescent device using same OR10J3, LEF1, RPL19 PDK2 3230/4885KDM4E 960/4885NPC1 3790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.