Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 15/20 | 0.77 |
| ▸ | CDK2 | P24941 | 15/20 | 0.77 |
| ▸ | CCNA1 | P78396 | 15/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 18/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930904 | 0.87 | CCNA2 (1.00) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL14516264 | 0.80 | CHEK1 (0.77) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL11931329 | 0.79 | CCNA2 (0.58) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL12953557 | 0.77 | CHEK1 (0.73) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL11931272 | 0.75 | CHEK1 (0.77) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL14043149 | 0.75 | CHEK1 (0.52) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL15026293 | 0.74 | CHEK1 (0.64) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL14543052 | 0.74 | CCNA2 (0.77) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL14231706 | 0.74 | CHEK1 (0.78) | CCNA2CDK2CCNA1CHEK1 | |
| SCHEMBL11931334 | 0.70 | CCNA2 (0.72) | CCNA2CDK2CCNA1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183933-A1 | NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS | MERCK SHARP & DOHME LLC | 2011-07-28 | — | — | US | disclosed |
| US-20070082900-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183933-A1 | NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS | CDC25C, CHEK1, CDC25A | CCNA2 85/4885CDK2 10/4885CCNA1 65/4885 |
| US-20070082900-A1 | Methods for inhibiting protein kinases | PIM1, AURKC, PIM3 | CCNA2 1270/4885CDK2 64/4885CCNA1 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.