Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 8/20 | 0.72 |
| ▸ | KCNQ2 | O43526 | 8/20 | 0.72 |
| ▸ | KCNQ5 | Q9NR82 | 6/20 | 0.72 |
| ▸ | KCNE1 | P15382 | 6/20 | 0.71 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.71 |
| ▸ | BACE1 | P56817 | 1/20 | 0.71 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.59 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.59 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16436052 | 0.88 | KCNQ3 (0.65) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516646 | 0.88 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516640 | 0.85 | KCNQ3 (0.74) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516679 | 0.85 | KCNQ3 (0.61) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516639 | 0.84 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5343768 | 0.84 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5214418 | 0.83 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL5348385 | 0.83 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516674 | 0.83 | KCNQ3 (0.81) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5346150 | 0.83 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |