Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 8/20 | 0.71 |
| ▸ | KCNQ2 | O43526 | 8/20 | 0.71 |
| ▸ | KCNQ5 | Q9NR82 | 6/20 | 0.71 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.71 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.71 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.64 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14516644 | 0.90 | KCNQ3 (0.74) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516646 | 0.86 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516645 | 0.84 | KCNQ3 (0.72) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5345894 | 0.83 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5217004 | 0.83 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1P4HTM | |
| SCHEMBL14516679 | 0.83 | KCNQ3 (0.61) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14854999 | 0.82 | BCAT2 (0.64) | KCNQ3KCNQ2BCAT2P4HTMKDR | |
| SCHEMBL5346150 | 0.81 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516640 | 0.80 | KCNQ3 (0.74) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL12190155 | 0.79 | HDAC6 (0.64) | KCNQ3KCNQ2BCAT2P4HTMKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |