Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 8/20 | 0.74 |
| ▸ | KCNQ2 | O43526 | 8/20 | 0.74 |
| ▸ | KCNE1 | P15382 | 6/20 | 0.74 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.74 |
| ▸ | KCNQ5 | Q9NR82 | 6/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.67 |
| ▸ | JUN | P05412 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | ATF1 | P18846 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14516645 | 0.85 | KCNQ3 (0.72) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL14339875 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1TRPV1 | |
| SCHEMBL5338598 | 0.84 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL14516646 | 0.83 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL14516679 | 0.81 | KCNQ3 (0.61) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL3135086 | 0.81 | KCNQ3 (0.86) | KCNQ3KCNQ2KCNE1KCNQ1TRPV1 | |
| SCHEMBL14516642 | 0.80 | KCNQ3 (0.77) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL14516643 | 0.80 | KCNQ3 (0.77) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL14516639 | 0.80 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL5645475 | 0.80 | KCNQ3 (0.72) | KCNQ3KCNQ2KCNE1KCNQ1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |