Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | CA9 | Q16790 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562134 | 0.89 | LMNA (1.00) | LMNATSHRMAPTTDP1CA1 | |
| SCHEMBL24347595 | 0.83 | LMNA (0.78) | LMNATSHRTDP1CA1CA2 | |
| SCHEMBL15298754 | 0.80 | LMNA (0.82) | LMNATSHRMAPTTDP1CA1 | |
| SCHEMBL15895028 | 0.80 | — | — | |
| SCHEMBL836383 | 0.80 | LMNA (0.82) | LMNATSHRMAPTTDP1CA1 | |
| SCHEMBL10064431 | 0.77 | — | — | |
| SCHEMBL13780478 | 0.77 | LMNA (0.45) | LMNATSHRTHPOMAPTTDP1 | |
| SCHEMBL12989977 | 0.77 | LMNA (0.75) | LMNATSHRHDAC3HDAC4KMT2A | |
| SCHEMBL429273 | 0.76 | — | — | |
| SCHEMBL8739500 | 0.75 | LMNA (0.72) | LMNATSHRTDP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555777-B1 | NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES | SIRNA THERAPEUTICS INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-7202033-B2 | Identification of kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |