Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14411208 | 0.94 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12KDM4E | |
| SCHEMBL5443213 | 0.83 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12TSHR | |
| SCHEMBL14411212 | 0.77 | ALOX5 (0.47) | MAPK14MAPK11MAPK1ALOX5 | |
| SCHEMBL14411229 | 0.77 | MAPK13 (0.40) | MAPK14MAPK11MAPK13MAPK12TSHR | |
| SCHEMBL5259316 | 0.76 | NPC1 (0.50) | MAPK14MAPK11MAPK13MAPK12KDM4E | |
| SCHEMBL7210339 | 0.75 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12TSHR | |
| SCHEMBL14519557 | 0.75 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12TSHR | |
| SCHEMBL14519570 | 0.75 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL6649751 | 0.72 | CYP2C19 (0.65) | TSHRKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL4585385 | 0.72 | ALOX5 (0.62) | MAPK14MAPK11MAPK13MAPK12ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | MAPK14 7/4885MAPK11 42/4885MAPK13 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.