Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671580 | 0.90 | CYP3A4 (0.56) | CYP2C19CYP3A4CYP2D6KDM4ENPC1 | |
| SCHEMBL6649060 | 0.85 | HRH3 (0.51) | CYP2C19CYP3A4CYP2D6L3MBTL1TDP1 | |
| SCHEMBL6651015 | 0.84 | CYP3A4 (0.53) | CYP2C19CYP3A4CYP2D6L3MBTL1TDP1 | |
| SCHEMBL1292252 | 0.84 | KMT2A (0.63) | CYP2C19GAAKDM4ENPC1RAB9A | |
| SCHEMBL8243016 | 0.83 | LMNA (0.58) | CYP2C19CYP3A4CYP2D6GAAKDM4E | |
| SCHEMBL19623580 | 0.81 | RAD52 (0.53) | CYP2C19CYP3A4CYP2D6GAAKDM4E | |
| SCHEMBL1955959 | 0.81 | NPC1 (0.51) | CYP2C19CYP3A4CYP2D6GAAKDM4E | |
| SCHEMBL996593 | 0.81 | RAB9A (0.50) | CYP2C19CYP3A4CYP2D6GAAKDM4E | |
| SCHEMBL3234489 | 0.81 | NPC1 (0.51) | CYP2C19CYP3A4CYP2D6GAAKDM4E | |
| SCHEMBL8300077 | 0.81 | CYP3A4 (0.56) | CYP2C19CYP3A4CYP2D6GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |