Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 15/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603313 | 0.86 | GRIK1 (0.62) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL13460162 | 0.84 | KDM4E (0.66) | ALDH1A1KDM4ESMN1; SMN2TSHRCASP1 | |
| SCHEMBL1321725 | 0.82 | KDM4E (0.63) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL17627435 | 0.82 | GRIK1 (0.58) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL29183052 | 0.82 | GRIK1 (0.68) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL11604092 | 0.81 | GRIK1 (0.57) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL5469866 | 0.79 | GRIK1 (0.55) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11604096 | 0.79 | KDM4E (0.60) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL5469868 | 0.79 | GRIK1 (0.55) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6750019 | 0.79 | KDM4E (0.75) | GRIK1ALDH1A1KDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073405-A1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-06-28 | — | — | WO | disclosed |