Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25951586 | 0.82 | CHRNB4 (0.57) | ALDH1A1MAPTCHRNA3HPGDPOLB | |
| SCHEMBL25951588 | 0.82 | CREBBP (0.40) | ALDH1A1MAPTGPR174CHRNA3MEN1 | |
| SCHEMBL1903629 | 0.81 | CYP2C9 (0.35) | ALDH1A1MAPTGPR174CHRNA3MEN1 | |
| SCHEMBL14524422 | 0.80 | MAPT (0.42) | ALDH1A1MAPTCHRNA3MEN1KMT2A | |
| SCHEMBL8018390 | 0.77 | CHRNB4 (0.38) | ALDH1A1MAPTCHRNA3HPGDPOLB | |
| SCHEMBL6824133 | 0.75 | KDM4E (0.45) | ALDH1A1MAPTCHRNA3CHRNB2CHRNA4 | |
| SCHEMBL14364782 | 0.74 | CHRNB4 (0.41) | ALDH1A1MAPTCHRNA3MEN1KMT2A | |
| SCHEMBL14003853 | 0.74 | CHRNB4 (0.41) | ALDH1A1MAPTCHRNA3MEN1KMT2A | |
| SCHEMBL29761227 | 0.74 | CHRNB4 (0.36) | ALDH1A1MAPTCHRNA3HPGDPOLB | |
| SCHEMBL25735077 | 0.74 | CHRNB4 (0.36) | ALDH1A1MAPTCHRNA3HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205300-B2 | Aryl fused azapolycyclic compounds | PFIZER INC (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205300-B2 | Aryl fused azapolycyclic compounds | PFIZER INC (US) | 2007-04-17 | — | — | US | disclosed |