Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408500 | 0.93 | KDM4E (0.47) | KDM4EMAPTALDH1A1LMNATHRB | |
| SCHEMBL29051883 | 0.79 | MAPT (0.52) | KDM4ECHRNB4CHRNA3MAPTALDH1A1 | |
| SCHEMBL4404226 | 0.77 | HCAR3 (0.46) | KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL4407178 | 0.77 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| Hydrochloric Acid SCHEMBL6824751 | 0.76 | CHRNB2 (0.58) | KDM4ECHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4417154 | 0.75 | KDM4E (0.51) | KDM4EMAPTTHRBNR1H2PDE4B | |
| SCHEMBL14524430 | 0.75 | ALDH1A1 (0.42) | CHRNB4CHRNA3MAPTALDH1A1CHRNB2 | |
| SCHEMBL24583314 | 0.72 | ALDH1A1 (0.44) | KDM4EMAPTALDH1A1LMNAPDE4B | |
| SCHEMBL31455485 | 0.72 | ALDH1A1 (0.44) | KDM4EMAPTALDH1A1LMNAPDE4B | |
| SCHEMBL19175230 | 0.72 | LMNA (0.44) | KDM4EMAPTALDH1A1LMNAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383733-A2 | PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002085843-A2 | PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2002-10-31 | — | — | WO | disclosed |