Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14524424 | 0.89 | SIRT6 (0.43) | MAPTKDM4ECHRNB4CHRNA3TSHR | |
| SCHEMBL8018390 | 0.82 | CHRNB4 (0.38) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL14524430 | 0.80 | ALDH1A1 (0.42) | MAPTCHRNB4CHRNA3POLBMEN1 | |
| SCHEMBL25735077 | 0.79 | CHRNB4 (0.36) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL29761227 | 0.79 | CHRNB4 (0.36) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL14364782 | 0.76 | CHRNB4 (0.41) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL14003853 | 0.76 | CHRNB4 (0.41) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL14668105 | 0.74 | CHRNB4 (0.65) | CHRNB4CHRNA3 | |
| SCHEMBL4407178 | 0.74 | CHRNB4 (0.65) | CHRNB4CHRNA3 | |
| SCHEMBL1903629 | 0.73 | CYP2C9 (0.35) | MAPTLMNACHRNB4CHRNA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205300-B2 | Aryl fused azapolycyclic compounds | PFIZER INC (US) | 2007-04-17 | — | — | US | disclosed |
| US-7186870-B2 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds | PFIZER INC (US) | 2007-03-06 | — | — | US | disclosed |