Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044469 | 0.84 | MAPT (0.39) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL3044470 | 0.84 | MAPT (0.39) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL3710894 | 0.72 | SIRT1 (0.39) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL3710891 | 0.72 | SIRT1 (0.39) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL1738 | 0.71 | MAPT (0.43) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL16502242 | 0.69 | KMT2A (0.45) | MAPTKMT2ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL3711787 | 0.69 | NPC1 (0.43) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL3711785 | 0.69 | NPC1 (0.43) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL13828453 | 0.68 | SMN1; SMN2 (0.45) | MAPTRAB9AKMT2ALMNAMAPK1 | |
| SCHEMBL29907949 | 0.68 | ELANE (0.44) | MAPTRAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012138797-A1 | 3- OR 5 - BI PHENYL - 4 - YLISOXAZOLE - BASED COMPOUNDS USEFUL FOR THE TREATMENT OF FIBROSIS, PAIN, CANCER AND RESPIRATORY, ALLERGIC, NERVOUS SYSTEM OR CARDIOVASCULAR DISORDERS | AMIRA PHARMACEUTICALS, INC. (US) | 2012-10-11 | — | — | WO | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |