Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14528894 | 0.95 | CHRM2 (0.38) | CHRM2CHRM1CHRM3KDM4EMEN1 | |
| SCHEMBL14529830 | 0.88 | CHRM2 (0.37) | CHRM2CHRM1CHRM3ALDH1A1HRH3 | |
| SCHEMBL14528399 | 0.88 | NAAA (0.43) | CHRM2CHRM1ALDH1A1HRH3NAAA | |
| SCHEMBL14528411 | 0.86 | CHRM2 (0.56) | CHRM2CHRM1CHRM3ALDH1A1HRH3 | |
| SCHEMBL14528414 | 0.86 | CARM1 (0.44) | NAAA | |
| SCHEMBL14528889 | 0.82 | NAAA (0.46) | CHRM2CHRM1MEN1ALDH1A1KMT2A | |
| SCHEMBL14528431 | 0.81 | PDE9A (0.36) | CHRM2CHRM1CHRM3HRH3ADRA1A | |
| SCHEMBL14528643 | 0.81 | CHRM2 (0.39) | CHRM2CHRM1CHRM3HRH3ADRA1A | |
| SCHEMBL14528920 | 0.81 | CHRM2 (0.57) | CHRM2CHRM1CHRM3KDM4EALDH1A1 | |
| SCHEMBL14528407 | 0.81 | ALDH1A1 (0.44) | ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053495-A2 | COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |