Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | PHGDH | O43175 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.57 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.57 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.57 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10720943 | 0.86 | PHGDH (0.81) | HPGDALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5235593 | 0.85 | HPGD (0.56) | HPGDALDH1A1KDM4EMAPTHTT | |
| SCHEMBL14529143 | 0.84 | L3MBTL3 (0.84) | ALDH1A1KDM4EL3MBTL1L3MBTL3MBTD1 | |
| SCHEMBL1359639 | 0.84 | HPGD (0.63) | HPGDALDH1A1KDM4EMAPTHTT | |
| SCHEMBL14528665 | 0.84 | L3MBTL3 (0.78) | ALDH1A1KDM4EL3MBTL1L3MBTL3MBTD1 | |
| SCHEMBL14982133 | 0.83 | GSK3B (0.58) | HPGDALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL28900568 | 0.82 | HPGD (0.59) | HPGDALDH1A1KDM4EMAPTHTT | |
| SCHEMBL28296651 | 0.80 | HPGD (0.86) | HPGDALDH1A1KDM4EMAPTHTT | |
| SCHEMBL30635500 | 0.79 | HPGD (0.90) | HPGDALDH1A1KDM4ESMN1; SMN2PHGDH | |
| SCHEMBL1360270 | 0.79 | HPGD (0.92) | HPGDALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053495-A2 | COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |