Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.46 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.46 |
| ▸ | F13A1 | P00488 | 5/20 | 0.40 |
| ▸ | TGM2 | P21980 | 5/20 | 0.40 |
| ▸ | TGM1 | P22735 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885055 | 0.90 | GSK3B (0.51) | TRPC3TRPC7F13A1TGM2TGM1 | |
| SCHEMBL13885057 | 0.83 | GSK3B (0.49) | TRPC3TRPC7F13A1TGM2TGM1 | |
| SCHEMBL13305054 | 0.83 | TRPC3 (0.53) | TRPC3TRPC7CYP2D6CYP2C9GRIN2B | |
| SCHEMBL13118082 | 0.80 | GSK3B (0.51) | TRPC3TRPC7CYP2D6CYP2C9GRIN2B | |
| SCHEMBL13998619 | 0.79 | GRIN2B (0.52) | TRPC3TRPC7CYP2D6CYP2C9GRIN2B | |
| SCHEMBL13885699 | 0.77 | GSK3B (0.43) | TRPC3TRPC7F13A1TGM2TGM1 | |
| SCHEMBL13998618 | 0.75 | GSK3B (0.54) | TRPC3TRPC7CYP2D6CYP2C9GRIN2B | |
| SCHEMBL14528946 | 0.75 | GSK3B (0.41) | TRPC3TRPC7F13A1TGM2TGM1 | |
| SCHEMBL12953550 | 0.73 | GSK3B (0.52) | TRPC3TRPC7CYP2D6CYP2C9GRIN2B | |
| SCHEMBL11931170 | 0.73 | GRIN2B (0.46) | TRPC3TRPC7F13A1TGM2TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |