Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CCR2 | P41597 | 7/20 | 0.61 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14528425 | 0.86 | GPR139 (0.62) | GPR139POLBALDH1A1HTTL3MBTL1 | |
| SCHEMBL8947129 | 0.84 | POLB (0.68) | GPR139POLBALDH1A1HTTL3MBTL1 | |
| SCHEMBL30407428 | 0.84 | POLB (0.67) | GPR139POLBALDH1A1HTTL3MBTL1 | |
| SCHEMBL613062 | 0.84 | POLB (0.67) | GPR139POLBALDH1A1HTTL3MBTL1 | |
| SCHEMBL1417591 | 0.83 | NPSR1 (0.69) | POLBALDH1A1HTTNPSR1 | |
| SCHEMBL30137430 | 0.83 | NPSR1 (0.69) | POLBALDH1A1HTTNPSR1 | |
| SCHEMBL7641409 | 0.82 | POLB (0.65) | GPR139POLBALDH1A1MRGPRX4HTT | |
| SCHEMBL30739602 | 0.82 | POLB (0.78) | GPR139POLBALDH1A1MRGPRX4TP53BP1 | |
| SCHEMBL2855037 | 0.82 | POLB (0.78) | GPR139POLBALDH1A1MRGPRX4TP53BP1 | |
| SCHEMBL23014295 | 0.81 | GPR139 (0.64) | GPR139POLBALDH1A1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452939-B1 | PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST | YANG JI CHEMICAL CO LTD (KR) | 2014-03-26 | — | — | EP | disclosed |
| WO-2007053498-A1 | COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |