Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.60 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 2/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613062 | 0.85 | POLB (0.67) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL30407428 | 0.85 | POLB (0.67) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL14528906 | 0.84 | GPR139 (0.66) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL16024734 | 0.84 | POLB (0.74) | POLBALDH1A1NPSR1TP53BP1TP53 | |
| SCHEMBL7641409 | 0.84 | POLB (0.65) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL2855037 | 0.83 | POLB (0.78) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL30739602 | 0.83 | POLB (0.78) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL23014295 | 0.82 | GPR139 (0.64) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL13332107 | 0.82 | POLB (0.63) | POLBALDH1A1NPSR1GPR139TP53BP1 | |
| SCHEMBL449754 | 0.82 | NPSR1 (0.57) | POLBALDH1A1NPSR1TP53BP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |