Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 9/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 3/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313143 | 0.88 | ACVRL1 (0.39) | ACVRL1RIPK1TNK2MERTKIGF1R | |
| SCHEMBL14327069 | 0.88 | ACVRL1 (0.39) | ACVRL1RIPK1TNK2MERTKIGF1R | |
| SCHEMBL14313149 | 0.86 | ACVRL1 (0.41) | ACVRL1RIPK1MERTK | |
| SCHEMBL5076878 | 0.83 | ACVRL1 (0.41) | ACVRL1RIPK1TNK2IGF1R | |
| SCHEMBL14327028 | 0.81 | ACVRL1 (0.40) | ACVRL1TNK2IGF1RINSRMET | |
| SCHEMBL14312981 | 0.80 | ACVRL1 (0.37) | ACVRL1TNK2MERTKIGF1RINSR | |
| SCHEMBL14313218 | 0.80 | ACVRL1 (0.44) | ACVRL1RIPK1MERTKMET | |
| SCHEMBL5074844 | 0.79 | ACVRL1 (0.43) | ACVRL1TNK2IGF1RINSRMET | |
| SCHEMBL14313018 | 0.79 | ACVRL1 (0.62) | ACVRL1TNK2MERTK | |
| SCHEMBL14313034 | 0.79 | RIPK1 (0.41) | ACVRL1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |