Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18511684 | 0.79 | CA2 (0.43) | PDK2CTSSP2RX7CTSKTSHR | |
| SCHEMBL9524633 | 0.77 | CTSS (0.56) | CTSSP2RX7CTSKTAS2R14 | |
| SCHEMBL30562236 | 0.77 | CTSS (0.56) | CTSSP2RX7CTSKTAS2R14 | |
| SCHEMBL3781319 | 0.75 | TSHR (0.48) | PDK2TSHRTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8681119 | 0.74 | NOTUM (0.41) | TSHRHTTPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL28659549 | 0.72 | CTSS (0.42) | PDK2CTSSP2RX7CTSKTAS2R14 | |
| SCHEMBL825860 | 0.72 | TSHR (0.49) | PDK2CTSSP2RX7CTSKTSHR | |
| SCHEMBL826478 | 0.72 | CTSS (0.36) | PDK2CTSSP2RX7CTSKTSHR | |
| SCHEMBL699212 | 0.70 | TSHR (0.65) | P2RX7TSHRHTTTAS1R3TAS1R1 | |
| SCHEMBL31004827 | 0.70 | TSHR (0.65) | P2RX7TSHRHTTTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056163-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |