Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14091240 | 0.84 | KDM4E (0.65) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL1895948 | 0.80 | NPC1 (0.55) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL7965438 | 0.79 | KDM4E (1.00) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8343381 | 0.77 | KDM4E (0.94) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL1206446 | 0.74 | ALDH1A1 (0.61) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL14091269 | 0.73 | KDM4E (0.51) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL32665694 | 0.71 | KDM4E (0.69) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL28671805 | 0.70 | NPC1 (0.65) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8343142 | 0.69 | KDM4E (0.80) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8343385 | 0.69 | KDM4E (0.80) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056155-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2007-05-18 | — | — | WO | disclosed |