Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316853 | 0.79 | CYP1A2 (0.40) | ALDH1A1HSD17B10L3MBTL1KDM4ENPC1 | |
| SCHEMBL786476 | 0.76 | ACP1 (0.51) | CYP3A4 | |
| SCHEMBL4773825 | 0.76 | HSP90AA1 (0.56) | ALDH1A1HSD17B10KDM4EGAAHSP90AA1 | |
| SCHEMBL31388225 | 0.74 | MEN1 (0.55) | ALDH1A1L3MBTL1KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL786133 | 0.74 | MEN1 (0.55) | ALDH1A1L3MBTL1KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL13804169 | 0.74 | PDPK1 (0.43) | ALDH1A1HSD17B10L3MBTL1KDM4EGAA | |
| SCHEMBL509219 | 0.72 | HSP90AA1 (0.56) | ALDH1A1HSD17B10KDM4EGAAHSP90AA1 | |
| SCHEMBL4766383 | 0.71 | ADORA2A (0.46) | ALDH1A1HSD17B10KDM4ENPC1HSP90AA1 | |
| SCHEMBL4769077 | 0.71 | MEN1 (0.44) | ALDH1A1L3MBTL1KDM4EGAAHSP90AA1 | |
| SCHEMBL22201436 | 0.70 | PRKCH (0.52) | ALDH1A1L3MBTL1KDM4ENPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099873-A1 | Quinolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099873-A1 | Quinolines useful as modulators of ion channels | KCNQ1, KCNQ2, KCNQ5 | ALDH1A1 2630/4885HSD17B10 3135/4885L3MBTL1 4089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.