Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766383 | 0.88 | ADORA2A (0.46) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4769077 | 0.86 | MEN1 (0.44) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4773101 | 0.85 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4765203 | 0.85 | MEN1 (0.55) | ALDH1A1SMN1; SMN2ADORA3KDM4EMAPT | |
| SCHEMBL4774988 | 0.85 | CYP2D6 (0.53) | ALDH1A1HPGDADORA3KDM4EHSD17B10 | |
| SCHEMBL29986134 | 0.79 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4771340 | 0.79 | KMT2A (0.61) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL13316853 | 0.79 | CYP1A2 (0.40) | ALDH1A1HPGDSMN1; SMN2METAP2KDM4E | |
| SCHEMBL3909868 | 0.77 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29137491 | 0.76 | ALDH1A1 (0.46) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532020-A | 5, 6, or 7-substituted -3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof | REXAHN PHARMACEUTICALS INC | 2012-07-04 | — | — | CN | disclosed |
| CN-101573337-B | 5, 6 or 7-substituted-3- (hetero) aryl-isoquinolinamine derivatives as antitumor agents | REXAHN PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | CN | disclosed |
| CN-101573337-A | 5, 6 or 7-substituted-3- (hetero) aryl-isoquinolinamine derivatives as antitumor agents | REXAHN PHARMACEUTICALS INC (US) | 2009-11-04 | — | — | CN | disclosed |
| EP-1020445-B1 | FUSED PYRIDINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-6875761-B2 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. | 2004-10-14 | — | — | US | disclosed |
| US-6790844-B2 | MUSCLE RELAXANTS; ANTISEROTONINE AGENT | EISAI CO., LTD (JP) | 2004-09-14 | — | — | US | disclosed |
| US-20020013460-A1 | Condensed pyridine compound | EISAI CO., LTD | 2002-01-31 | — | — | US | disclosed |
| US-6340759-B1 | ANTISPASMODIC AGENTS | EISAI CO., LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1020445-A1 | FUSED PYRIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013460-A1 | Condensed pyridine compound | MUSK, HTR1A, PAX3 | HSP90AA1 2106/4885HSP90AB1 2551/4885ALDH1A1 2989/4885 |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | MUSK, HTR1A, RYR1 | HSP90AA1 2132/4885HSP90AB1 2339/4885ALDH1A1 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.