Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25030467 | 0.98 | NAAA (0.39) | NAAAEPHX1NPC1EPHX2GAA | |
| SCHEMBL26062113 | 0.89 | NAAA (0.36) | NAAAEPHX1NPC1EPHX2GAA | |
| SCHEMBL31034456 | 0.86 | CHRM2 (0.36) | EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL14343054 | 0.85 | EPHX2 (0.38) | EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL27358924 | 0.85 | EPHX2 (0.32) | EPHX2 | |
| SCHEMBL2566341 | 0.85 | USP2 (0.37) | EPHX2SMN1; SMN2 | |
| SCHEMBL31034510 | 0.83 | DDB1 (0.33) | EPHX2 | |
| SCHEMBL27436810 | 0.81 | EPHX1 (0.37) | NAAAEPHX1EPHX2GAAHTT | |
| SCHEMBL30103387 | 0.81 | CHRM2 (0.40) | EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL23295591 | 0.81 | EPHX2 (0.36) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062314-A2 | HETEROCYCLIC CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007062308-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |