Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14508899 | 0.88 | KMT2A (0.47) | ALDH1A1TDP1RAB9AFOLH1SLC7A5 | |
| SCHEMBL14534518 | 0.88 | ALDH1A1 (0.41) | ALDH1A1TDP1TSHRCYP3A4MAPK1 | |
| SCHEMBL26424287 | 0.84 | FOLH1 (0.50) | ALDH1A1TDP1TSHRCYP3A4MAPK1 | |
| SCHEMBL26424285 | 0.81 | LTA4H (0.42) | ALDH1A1TDP1TSHRCYP3A4MAPK1 | |
| SCHEMBL14508890 | 0.80 | TDP1 (0.54) | ALDH1A1TDP1RAB9AFOLH1SLC7A5 | |
| SCHEMBL14534516 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TDP1TSHRCYP3A4MAPK1 | |
| SCHEMBL18969810 | 0.76 | TDP1 (0.72) | ALDH1A1TDP1TSHRCYP3A4MAPK1 | |
| SCHEMBL23704713 | 0.73 | FOLH1 (0.55) | RAB9AFOLH1NPC1 | |
| SCHEMBL14534743 | 0.73 | KMT2A (0.54) | ALDH1A1TDP1RAB9AFOLH1SLC7A5 | |
| SCHEMBL14508891 | 0.73 | TDP1 (0.50) | ALDH1A1TDP1RAB9AFOLH1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | disclosed |