Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16485934 | 0.82 | — | — | |
| SCHEMBL27548088 | 0.79 | EPHX1 (0.35) | HSD11B1CYP2C19 | |
| SCHEMBL19433874 | 0.78 | HSD11B1 (0.37) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL2453547 | 0.77 | GRM4 (0.35) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL4565712 | 0.77 | GRM4 (0.35) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL4565617 | 0.77 | GRM4 (0.35) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL28068725 | 0.77 | HSD11B1 (0.44) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL25218266 | 0.76 | GRM4 (0.38) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL9939044 | 0.74 | SLC1A2 (0.41) | HSD11B1CES2CES1LMNATSHR | |
| SCHEMBL28507194 | 0.74 | GRM4 (0.41) | HSD11B1CES2CES1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |