SCHEMBL14536697

SCHEMBL14536697

CCc1nc(C2CCC2)n2ncnc(N)c12

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TNK2 Q07912 19/20 0.55
IGF1R P08069 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13618206 0.82 TNK2 (0.55) TNK2IGF1R
SCHEMBL397549 0.79 TNK2 (0.55) TNK2IGF1R
SCHEMBL25168436 0.76 TNK2 (0.52) TNK2IGF1R
SCHEMBL14647486 0.75 PDE2A (0.39)
SCHEMBL593101 0.75 TNK2 (0.51) TNK2IGF1R
SCHEMBL14473314 0.74 ACVRL1 (0.36) TNK2
SCHEMBL8240001 0.74 TNK2 (0.83) TNK2IGF1R
SCHEMBL31391110 0.73 TNK2 (0.48) TNK2IGF1R
SCHEMBL31391188 0.73 TNK2 (0.48) TNK2IGF1R
SCHEMBL14536967 0.72 PDE5A (0.39) TNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007061737-A2 FUSED BICYCLIC mTOR INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2007-05-31 WO disclosed