Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14473314 | 0.82 | ACVRL1 (0.36) | ACVRL1ADORA2A | |
| SCHEMBL10248850 | 0.79 | PDE2A (0.42) | PDE2AACVRL1ADORA2A | |
| SCHEMBL13201570 | 0.76 | PDE2A (0.41) | PDE2AACVRL1ADORA2A | |
| SCHEMBL17114650 | 0.76 | MEN1 (0.35) | PDE2APDE10A | |
| SCHEMBL14536697 | 0.75 | TNK2 (0.55) | — | |
| SCHEMBL14654141 | 0.73 | ADORA2A (0.39) | ACVRL1ADORA2APDE10A | |
| SCHEMBL13077692 | 0.73 | RET (0.40) | PDE2AACVRL1ADORA2APDE10A | |
| SCHEMBL14647493 | 0.73 | ACVRL1 (0.39) | ACVRL1ADORA2A | |
| SCHEMBL23960263 | 0.70 | BTK (0.46) | — | |
| SCHEMBL279744 | 0.70 | FGFR1 (0.40) | ACVRL1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548877-A1 | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors | MSD Oss B.V. (NL) | 2013-01-23 | — | — | EP | disclosed |