Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.34 |
| ▸ | MAPKAPK5 | Q8IW41 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246540 | 0.87 | AURKA (0.54) | AURKAPTK6AURKBTTKMAPKAPK5 | |
| SCHEMBL8427842 | 0.70 | AURKA (0.32) | AURKAPTK6AURKBMAPKAPK5 | |
| SCHEMBL14529931 | 0.68 | AURKB (0.68) | AURKAAURKB | |
| SCHEMBL14536774 | 0.67 | AURKA (0.38) | AURKAPTK6AURKBTTKMAPKAPK5 | |
| SCHEMBL8240292 | 0.66 | AURKA (0.70) | AURKAPTK6AURKBTTKMAPKAPK5 | |
| SCHEMBL14536951 | 0.65 | AURKA (0.37) | AURKAAURKBTTK | |
| SCHEMBL14537044 | 0.64 | AURKA (0.45) | AURKAPTK6AURKBTTKMAPKAPK5 | |
| SCHEMBL8241606 | 0.64 | AURKA (0.58) | AURKAPTK6AURKBMAPKAPK5 | |
| SCHEMBL8240330 | 0.64 | AURKA (0.63) | AURKAPTK6AURKBTTKMAPKAPK5 | |
| SCHEMBL14537085 | 0.63 | AURKA (0.46) | AURKAPTK6AURKBTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |