Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241606 | 0.89 | AURKA (0.58) | AURKAFGFR2FLT3MAPKAPK5SYK | |
| SCHEMBL14537040 | 0.84 | AURKA (0.48) | AURKAMAPKAPK5AURKBPTK6TTK | |
| SCHEMBL3468104 | 0.81 | FGFR2 (0.42) | AURKAFGFR2FLT3MAPKAPK5SYK | |
| SCHEMBL14536853 | 0.81 | AURKA (0.46) | AURKAFLT3MAPKAPK5AURKBPTK6 | |
| SCHEMBL3470478 | 0.81 | MAPKAPK5 (0.43) | AURKAFGFR2FLT3MAPKAPK5SYK | |
| SCHEMBL11939505 | 0.80 | FLT1 (0.47) | FGFR2FLT3MAPKAPK5SYKEGFR | |
| SCHEMBL1674087 | 0.79 | MAPKAPK5 (0.60) | AURKAFGFR2FLT3MAPKAPK5SYK | |
| SCHEMBL14536959 | 0.79 | TTK (0.54) | AURKAMAPKAPK5AURKBTTK | |
| SCHEMBL14530182 | 0.79 | AURKA (0.53) | AURKAFLT3MAPKAPK5AURKBTTK | |
| SCHEMBL3469745 | 0.79 | ABL1 (0.51) | AURKAFGFR2FLT3MAPKAPK5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |