Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 14/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 8/20 | 0.48 |
| ▸ | NRAS | P01111 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954945 | 1.00 | PTK6 (0.53) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL8239892 | 0.86 | AURKA (0.56) | PTK6AURKBAURKALCKFLT3 | |
| SCHEMBL8241321 | 0.86 | AURKA (0.56) | PTK6AURKBAURKALCKFLT3 | |
| SCHEMBL14538358 | 0.78 | PTK6 (0.75) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL14536960 | 0.77 | MAPKAPK5 (0.62) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL14538620 | 0.76 | PTK6 (0.59) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL30138985 | 0.74 | MAPKAPK5 (0.62) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL8246328 | 0.74 | AURKA (0.56) | PTK6AURKBAURKATTK | |
| SCHEMBL13954839 | 0.73 | PTK6 (0.55) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL14529968 | 0.73 | PTK6 (0.49) | PTK6AURKBAURKAMAPKAPK5LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |