Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 8/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240802 | 0.84 | AURKA (0.66) | AURKAAURKBFLT3TTKAXL | |
| SCHEMBL14536731 | 0.84 | AURKA (0.49) | AURKAAURKBFLT3TTKAXL | |
| SCHEMBL10161077 | 0.72 | MAPKAPK5 (0.55) | AURKAAURKBGRM4 | |
| SCHEMBL30806208 | 0.70 | GRM4 (0.38) | AURKAAURKBGRM4 | |
| SCHEMBL8246421 | 0.70 | AURKA (0.63) | AURKAAURKBFLT3TTK | |
| SCHEMBL14530166 | 0.70 | AURKA (0.48) | AURKAAURKBFLT3TTK | |
| SCHEMBL14536958 | 0.69 | AURKA (0.36) | AURKAAURKBFLT3TTKGRM4 | |
| SCHEMBL8239869 | 0.69 | AURKA (0.68) | AURKAAURKBFLT3TTK | |
| SCHEMBL13954584 | 0.67 | AURKA (0.53) | AURKAAURKBFLT3TTK | |
| SCHEMBL8239874 | 0.67 | AURKA (0.69) | AURKAAURKBFLT3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |