Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 3/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529936 | 0.81 | PTK6 (0.35) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536830 | 0.77 | AURKA (0.37) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536731 | 0.75 | AURKA (0.49) | AURKAAURKBGRM4TTKFLT3 | |
| SCHEMBL8240802 | 0.73 | AURKA (0.66) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14530155 | 0.71 | AURKA (0.43) | AURKAAURKBTTKFLT3ADORA3 | |
| SCHEMBL30806208 | 0.69 | GRM4 (0.38) | AURKAAURKBGRM4ADORA3 | |
| SCHEMBL10161077 | 0.69 | MAPKAPK5 (0.55) | AURKAAURKBGRM4 | |
| SCHEMBL14537013 | 0.69 | AURKA (0.48) | AURKAAURKBGRM4TTKFLT3 | |
| SCHEMBL14529900 | 0.68 | TTK (0.50) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537080 | 0.68 | AURKA (0.45) | AURKAAURKBTTKFLT3ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |