Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.49 |
| ▸ | TTK | P33981 | 6/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240802 | 0.86 | AURKA (0.66) | AURKAAURKBTTKFLT3MAPKAPK5 | |
| SCHEMBL14537013 | 0.84 | AURKA (0.48) | AURKAAURKBTTKFLT3AXL | |
| SCHEMBL14530166 | 0.84 | AURKA (0.48) | AURKAAURKBTTKFLT3MAPKAPK5 | |
| SCHEMBL13954584 | 0.82 | AURKA (0.53) | AURKAAURKBTTKFLT3MAPKAPK5 | |
| SCHEMBL14537008 | 0.80 | AURKA (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536853 | 0.79 | AURKA (0.46) | AURKAAURKBTTKFLT3MAPKAPK5 | |
| SCHEMBL14530182 | 0.79 | AURKA (0.53) | AURKAAURKBTTKFLT3MAPKAPK5 | |
| SCHEMBL14536959 | 0.79 | TTK (0.54) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14538587 | 0.77 | AURKA (0.44) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537007 | 0.76 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |