Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.44 |
| ▸ | KDM1A | O60341 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 9/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9130854 | 0.74 | ALDH1A1 (0.42) | MAOBKDM1AALDH1A1MAOAHTR2C | |
| SCHEMBL695560 | 0.74 | ALDH1A1 (0.42) | MAOBKDM1AALDH1A1TAAR1CYP1A2 | |
| SCHEMBL17652437 | 0.74 | ALDH1A1 (0.42) | MAOBKDM1AALDH1A1MAOATAAR1 | |
| SCHEMBL28431861 | 0.74 | ALDH1A1 (0.42) | MAOBKDM1AALDH1A1MAOAHTR2C | |
| SCHEMBL14974371 | 0.74 | ALDH1A1 (0.42) | MAOBKDM1AALDH1A1HSD17B10 | |
| Biphenyl SCHEMBL27474545 | 0.73 | ALDH1A1 (0.56) | MAOBKDM1AALDH1A1MAOACYP2C19 | |
| Biphenyl SCHEMBL2574161 | 0.66 | ALDH1A1 (0.82) | ALDH1A1MAOATAAR1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL9388941 | 0.66 | ALDH1A1 (0.82) | ALDH1A1MAOACYP2B6TAAR1CYP1A2 | |
| Biphenyl SCHEMBL164 | 0.65 | ALDH1A1 (1.00) | ALDH1A1MAOACYP2B6TAAR1CYP1A2 | |
| Biphenyl SCHEMBL2548048 | 0.65 | ALDH1A1 (1.00) | ALDH1A1MAOACYP2B6TAAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130143824-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| US-20120058953-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20110039324-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2011-02-17 | — | — | US | disclosed |
| US-20090148921-A1 | Compositions and methods for enhancing apoptosis | GENENTECH, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20040171554-A1 | Compositions and methods for enhancing apoptosis | GENENTECH, INC. | 2004-09-02 | — | — | US | disclosed |