Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 10/20 | 0.51 |
| ▸ | AURKA | O14965 | 9/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537338 | 0.85 | NTRK1 (0.56) | AURKBAURKANTRK2EGFRERBB4 | |
| SCHEMBL1926391 | 0.84 | AURKB (0.55) | AURKBAURKANTRK2EGFRERBB4 | |
| SCHEMBL3978760 | 0.83 | NTRK1 (0.72) | AURKBAURKANTRK2EGFRERBB4 | |
| SCHEMBL14537179 | 0.82 | NTRK2 (0.56) | AURKBAURKANTRK2EGFRERBB4 | |
| SCHEMBL5597878 | 0.75 | MEN1 (0.53) | MAPK1 | |
| SCHEMBL5597764 | 0.75 | NPC1 (0.53) | GSK3B | |
| SCHEMBL5597907 | 0.75 | DDX3X (0.57) | KDRFLT3 | |
| SCHEMBL7050959 | 0.74 | HDAC6 (0.44) | — | |
| SCHEMBL4710759 | 0.72 | NTRK1 (0.52) | AURKBAURKANTRK2EGFRERBB4 | |
| SCHEMBL5597514 | 0.71 | TRPV1 (0.44) | KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |