Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14538164 | 0.86 | SLC6A2 (0.51) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL24762019 | 0.86 | SLC6A2 (0.57) | SLC6A2SLC6A4KCNH2SLC6A3LMNA | |
| SCHEMBL14538099 | 0.85 | SLC6A2 (0.50) | SLC6A2SLC6A4KCNH2SLC6A3LMNA | |
| SCHEMBL3561029 | 0.83 | SLC6A2 (0.55) | SLC6A2SLC6A4KCNH2SLC6A3LMNA | |
| SCHEMBL5463692 | 0.80 | LMNA (0.41) | LMNAALDH1A1GAANPSR1PKM | |
| SCHEMBL10327911 | 0.80 | SLC6A4 (0.75) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL549100 | 0.78 | CNR1 (0.47) | SLC6A2SLC6A4KCNH2SLC6A3LMNA | |
| SCHEMBL17277410 | 0.74 | SLC6A2 (0.53) | SLC6A2SLC6A4KCNH2SLC6A3LMNA | |
| SCHEMBL14490326 | 0.74 | GPR119 (0.48) | ALDH1A1NPSR1 | |
| SCHEMBL29764445 | 0.73 | SLC6A2 (0.57) | SLC6A2SLC6A4KCNH2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056075-A2 | SIX MEMBERED HETEROAROMATIC INHIBITORS TARGETING RESISTANT KINASE MUTATIONS | TARGEGEN, INC. (US) | 2007-05-18 | — | — | WO | disclosed |