Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621418 | 0.79 | RORC (0.42) | RORCMAPTNR1I2NR1H2NR1H3 | |
| SCHEMBL3621415 | 0.79 | RORC (0.42) | RORCMAPTNR1I2NR1H2NR1H3 | |
| SCHEMBL14537965 | 0.77 | RORC (0.51) | RORCMAPTKMT2ANR1I2NR1H2 | |
| SCHEMBL3626261 | 0.75 | RORC (0.53) | RORCNR1I2NR1H2NR1H3CYP1A2 | |
| SCHEMBL3619476 | 0.74 | RORC (0.57) | RORCNR1I2NR1H2NR1H3CYP1A2 | |
| SCHEMBL3620207 | 0.73 | RORC (0.51) | RORCNR1I2NR1H2NR1H3 | |
| SCHEMBL3625125 | 0.72 | RORC (0.55) | RORCNR1I2NR1H2NR1H3 | |
| SCHEMBL10047918 | 0.71 | MAPT (0.68) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL3618289 | 0.67 | NR1H3 (0.51) | NR1H2NR1H3 | |
| SCHEMBL4640318 | 0.67 | RORC (0.41) | RORCNR1I2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050425-A2 | LXR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-03 | — | — | WO | disclosed |