Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242483 | 0.90 | RORC (0.42) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3621418 | 0.86 | RORC (0.42) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3621415 | 0.86 | RORC (0.42) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL16242273 | 0.80 | RORC (0.44) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3625489 | 0.77 | RORC (0.48) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3625482 | 0.77 | RORC (0.48) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3626827 | 0.76 | LMNA (0.48) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3626831 | 0.76 | LMNA (0.48) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3615387 | 0.75 | RORC (0.49) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3615393 | 0.75 | RORC (0.49) | RORCNR1H3NR1I2NR1H2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951676-A2 | LXR MODULATORS | Brystol-Myers Squibb Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007050425-A2 | LXR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-03 | — | — | WO | disclosed |